A Tradition of Quality & Excellence
– Long-established riboflavin supply combining innovative science and research with German manufacturing excellence
– CE Marked products available worldwide since 2001
– Everyday, 8 out of 10 cross-linking patients are served with Avedro riboflavin
– Compliant with Annex V of EC-Directive 93/42/EEC
– ISO 13485 Certified manufacturer and facility
– Produced in world-class clean-room; sterilized using validated and monitored processes
Our riboflavin formulations have been specifically designed to address the following cross-linking protocols:
– Epithelium-off treatment of keratoconus and corneal ectasia
– Trans-epithelial treatment of keratoconus and corneal ectasia
– Intra-stromal applications in conjunction with LASIK (Lasik Xtra®)
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MedioCROSS M

MedioCROSS M is formulated with no dextran thus reducing corneal thinning. It has a diffusion rate of twice that of standard riboflavin with dextran thus shortening induction time by half. MedioCROSS M is topically applied to the cornea after epithelium removal, then UVA light is applied to activate it for cross-linking.
TECHNICAL INFORMATION
Formulation
– 0.1% Riboflavin, 1.1% HPMC
Procedure
– Cross-linking for keratoconus and corneal ectasia
Application
– Epithelium-off